Medicinal chemistry 4th semester imp questions with answer || all unit notes || 50 plus MCQ questions

Medicinal chemistry 4th semester imp questions with answer || all unit notes || 50 plus MCQ questions.


B pharmacy 4th semester Medicinal chemistry All syllabus notes [CSVTU]


Previous year question paper 2022-23
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                          ALL UNIT NOTES 
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Introduction to Medicinal Chemistry
History and development of medicinal chemistry
Physicochemical properties in relation to biological action
Ionization, Solubility, Partition Coefficient, Hydrogen bonding, Protein binding, Chelation, Bioisosterism, Optical and Geometrical isomerism


Drug metabolism
Drug metabolism principles- Phase I and Phase II

Factors affecting drug metabolism including stereo chemical aspects.


Drugs acting on Autonomic Nervous System
Adrenergic Neurotransmitters:
Biosynthesis and catabolism of catecholamine.

Adrenergic receptors (Alpha & Beta) and their distribution.


Sympathomimetic agents: SAR of Sympathomimetic agents
Direct acting: Nor-epinephrine, Epinephrine, Phenylephrine\*, Dopamine, Methyldopa, Clonidine, Dobutamine, Isoproterenol, Terbutaline, Salbutamol\*, Bitolterol, Naphazoline, Oxymetazoline and Xylometazoline.
Indirect acting agents: Hydroxyamphetamine, Pseudoephedrine, Propylhexedrine.
Agents with mixed mechanism: Ephedrine, Metaraminol.


Cholinergic neurotransmitters:
Biosynthesis and catabolism of acetylcholine.

Cholinergic receptors (Muscarinic & Nicotinic) and their distribution.


Parasympathomimetic agents: SAR of Parasympathomimetic agents
Direct acting agents:
Acetylcholine, Carbachol\*, Bethanechol, Methacholine, Pilocarpine.


Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible):
Physostigmine, Neostigmine\*, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion.


Cholinesterase reactivator:
Pralidoxime chloride.


Cholinergic Blocking agents: SAR of cholinolytic agents
Synthetic cholinergic blocking agents:
Atropine sulphate, Hyoscyamine sulphate, Scopolamine hydrobromide, Homatropine hydrobromide, Ipratropium bromide*.

Synthetic cholinergic blocking agents:
Tropicamide, Cyclopentolate hydrochloride, Clidinium bromide, Dicyclomine hydrochloride\*, Glycopyrrolate, Methantheline bromide, Propantheline bromide, Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride, Procyclidine hydrochloride\*, Tridihexethyl chloride, Isopropamide iodide, Ethopropazine hydrochloride.


Drugs acting on Central Nervous System

1. Sedatives and Hypnotics
Benzodiazepines:

SAR of Benzodiazepines, Chlordiazepoxide, Diazepam\*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam, Zolpidem

Barbiturtes:

SAR of barbiturates, Barbital\*, Phenobarbital, Mephobarbital, Amobarbital, Butabarbital, Pentobarbital, Secobarbital

Miscelleneous:

Amides & imides: Glutethmide.

Alcohol & their carbamate derivatives: Meprobomate, Ethchlorvynol.

Aldehyde & their derivatives: Triclofos sodium, Paraldehyde.


2. B
Phenothiazeines:

SAR of Phenothiazeines - Promazine hydrochloride, Chlorpromazine hydrochloride\*,

Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride,

Prochlorperazine maleate, Trifluoperazine hydrochloride.

Ring Analogues of Phenothiazeines:

Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine.

Fluro buterophenones: Haloperidol, Droperidol, Risperidone.

Beta amino ketones: Molindone hydrochloride.

Benzamides: Sulpieride.


Drugs acting on Central Nervous System
General anesthetics:
Inhalation anesthetics: Halothane\*, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane, Desflurane.

Ultra short acting barbitutrates: Methohexital sodium\*, Thiamylal sodium, Thiopental sodium.

Dissociative anesthetics: Ketamine hydrochloride.\*


Narcotic and non-narcotic analgesics
Morphine and related drugs: SAR of Morphine analogues, Morphine sulphate, Codeine, Meperidine hydrochloride, Anilerdine hydrochloride, Diphenoxylate hydrochloride, Loperamide hydrochloride, Fentanyl citrate\*, Methadone hydrochloride\*, Propoxyphene hydrochloride, Pentazocine, Levorphanol tartarate.

Narcotic antagonists: Nalorphine hydrochloride, Levallorphan tartarate, Naloxone hydrochloride.

Anti-inflammatory agents: Sodium salicylate, Aspirin, Mefenamic acid\*, Meclofenamate, Indomethacin, Sulindac, Tolmetin, Zomepriac, Diclofenac, Ketorolac, Ibuprofen\*, Naproxen, Piroxicam, Phenacetin, Acetaminophen, Antipyrine, Phenylbutazone.

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Most Important questions jo her saal repit hote hai



  • Explain the concept of structure-activity relationship (SAR) in medicinal chemistry. How is SAR used in drug design and optimization?

  • Discuss the different stages of the drug discovery and development process. Highlight the role of medicinal chemistry in this process.

  • Describe the mechanism of drug-receptor interactions. Differentiate between agonists and antagonists, providing examples of each.

  • Compare and contrast structure-based drug design (SBDD) and ligand-based drug design (LBDD). Give examples of drugs developed using each approach.

  • Discuss the medicinal chemistry of antibiotics. Explain how the mode of action of antibiotics differs from that of other antimicrobial agents.

  • Describe the medicinal chemistry of antipsychotic drugs. What are the primary targets and mechanisms of action for these drugs?

  • Explain the concept of prodrugs. Provide examples of prodrugs and discuss their advantages in drug design.

  • Discuss the medicinal chemistry of anti-cancer drugs. How do targeted therapies differ from conventional chemotherapy?

  • Explain the pharmacokinetic parameters of a drug. How does drug metabolism influence the pharmacokinetics of a compound?

  • Describe the different routes of drug administration and their advantages and disadvantages. Discuss the factors that influence the selection of a particular route for drug delivery.

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